Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Stroke Volume

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An unusual origin of the left coronary system.

BMJ case reports·2025

Same author

Optimising HER2-positive Breast Cancer Treatment: Insights on Subcutaneous Pertuzumab-trastuzumab Transition.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025

Same author

High-Statistics Measurement of the Cosmic-Ray Electron Spectrum with H.E.S.S.

Physical review letters·2024

Same author

Patient-centric comparative analysis of experiences in open upright and conventional closed MRI scanners.

Radiography (London, England : 1995)·2024

Same author

[Fulminant amniotic fluid embolism with subsequent cesarean section under prolonged resuscitation-A case report].

Die Anaesthesiologie·2024

Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

Population-based study of wake-up strokes.

J Mackey¹, D Kleindorfer, H Sucharew

¹University of Cincinnati, Department of Neurology, Cincinnati, OH 45219, USA. jason.mackey@uc.edu

|May 11, 2011

Summary

Approximately 14% of ischemic strokes are wake-up strokes, presenting similar clinical features and outcomes to other strokes. These findings highlight the significant proportion of wake-up strokes in the population.

More Related Videos

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Published on: March 15, 2024

Related Experiment Videos

Last Updated: Jun 2, 2026

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Published on: March 15, 2024

Area of Science:

Neurology
Epidemiology
Public Health

Background:

Wake-up strokes are ischemic strokes where symptom onset is unknown.
Previous estimates of wake-up stroke prevalence (8-28%) were based on small or non-population-based studies.

Purpose of the Study:

To determine the proportion and event rate of wake-up strokes in a large, population-based cohort.
To compare clinical features and outcomes of wake-up stroke patients with those of awake-onset stroke patients.

Main Methods:

A population-based study identified ischemic strokes in the Greater Cincinnati/Northern Kentucky region (1.3 million population) in 2005.
International Classification of Diseases-9 codes (430-436) were used for initial identification, followed by physician review for verification.
Included patients aged 18+ presenting to emergency departments, collecting baseline characteristics, modified Rankin Scale scores, and 90-day mortality.

Main Results:

1,854 ischemic strokes were identified, with 273 (14.3%) classified as wake-up strokes.
No significant differences in clinical features or outcomes were observed between wake-up and awake-onset strokes.
The adjusted wake-up stroke event rate was 26.0 per 100,000 population; 35.9% of wake-up strokes were potentially eligible for thrombolysis.

Conclusions:

Wake-up strokes constitute approximately 14% of emergency department ischemic strokes in this population.
Clinical presentation and outcomes do not differentiate wake-up strokes from other ischemic strokes.
An estimated 58,000 wake-up stroke patients presented to US emergency departments in 2005.