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Efficacy and safety of azithromycin for uncomplicated typhoid fever: an open label non-comparative study

Anju Aggarwal1, Apurba Ghosh, Sunil Gomber

  • 1Department of Pediatrics, University College of Medical Sciences and Guru Tegh Bahadur Hospital, New Delhi, India.

Indian Pediatrics
|May 11, 2011
PubMed

Insights

Azithromycin effectively treated uncomplicated typhoid fever in children. The antibiotic demonstrated high clinical cure rates and was well-tolerated, showing it to be a safe and efficacious option.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Therapy

Background:

  • Typhoid fever remains a significant public health concern, particularly in resource-limited settings.
  • Effective and safe treatment options for pediatric typhoid fever are crucial for reducing morbidity and mortality.

Purpose of the Study:

  • To evaluate the efficacy and safety of azithromycin for treating uncomplicated typhoid fever in children aged 2-12 years.
  • To assess clinical and bacteriological cure rates and adverse events associated with azithromycin treatment.

Main Methods:

  • An open-labelled, non-comparative study involving 117 children with uncomplicated typhoid fever.
  • Azithromycin administered at 20mg/kg/day for 6 days.
  • Clinical assessment and BACTEC blood cultures were used to determine outcomes.

Main Results:

  • A clinical cure rate of 93.5% was observed in 102 children who completed the study.
  • Bacteriological cure was achieved in all 17 patients with positive blood cultures for Salmonella typhi.
  • No serious adverse events were reported, with good global well-being in 95% of cases.

Conclusions:

  • Azithromycin is a safe and efficacious antibiotic for managing uncomplicated typhoid fever in children.
  • The study supports the use of azithromycin as a viable treatment option for pediatric typhoid fever.
  • Further research could explore azithromycin's role in multidrug-resistant typhoid strains.

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