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Updated: Jun 2, 2026
06:48
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells
Lizhi He1, Catherine Fan, Anil Kapoor
1Division of Nephrology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 4A6.
Nature Communications
|May 11, 2011
Summary
Alpha-mannosidase 2C1 (MAN2C1) inhibits phosphatase and tensin homolog (PTEN) function in prostate cancer cells. MAN2C1 promotes tumor growth by activating AKT signaling, highlighting its role as a PTEN-negative regulator.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- PTEN dephosphorylates phosphatidylinositol 3,4,5 triphosphate (PIP(3)), inhibiting AKT activation.
- PTEN dysfunction is crucial in tumorigenesis, but mechanisms remain unclear.
Purpose of the Study:
- To investigate the role of alpha-mannosidase 2C1 (MAN2C1) in regulating PTEN function in prostate cancer (PC).
Main Methods:
- Investigated MAN2C1's effect on PTEN in PC cells and patient samples.
- Analyzed PTEN and AKT activation in relation to MAN2C1 expression.
- Examined MAN2C1-PTEN interaction and its impact on PIP(3) phosphatase activity.
Main Results:
- MAN2C1 inhibits PTEN function and activates AKT in PC cells.
- MAN2C1 overexpression correlates with PTEN-positive tumors and PC recurrence.
- MAN2C1 binds PTEN, impairing its PIP(3) phosphatase activity.
Conclusions:
- MAN2C1 acts as a PTEN-negative regulator in prostate cancer.
- MAN2C1 promotes tumor growth by inhibiting PTEN and activating AKT.
- MAN2C1 is a potential therapeutic target in PTEN-positive prostate cancer.
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