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Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
p63 expression in randomized odontogenic cysts
Maryam Seyedmajidi1, Shahryar Shafaee, Ensieh Shafigh
1Department of Oral & Maxillofacial Pathology, Dental Materials Research Center, Dental Faculty, Babol University of Medical Sciences, PO Box 853, Babol, Mazandaran, Iran. ms_majidi79@yahoo.com
Saudi Medical Journal
|May 11, 2011
Summary
p63 protein expression was highest in keratocystic odontogenic tumors (KCOTs) compared to other odontogenic cysts. This finding may help identify aggressive cyst types.
Area of Science:
- Oral pathology
- Oncology
- Biomarkers
Background:
- Odontogenic cysts exhibit variable clinical behaviors.
- Immunohistochemical markers can aid in differentiating cyst types.
- p63 is a protein expressed in basal cells of various epithelia.
Purpose of the Study:
- To assess p63 protein expression in different odontogenic cysts.
- To correlate p63 expression levels with the clinical behavior of these cysts.
- To evaluate p63 as a potential diagnostic marker for aggressive odontogenic lesions.
Main Methods:
- Analysis of 34 archival paraffin-embedded odontogenic cyst specimens.
- Specimens included dentigerous cysts, radicular cysts, and keratocystic odontogenic tumors (KCOTs).
- Immunohistochemical staining using the Envision system was performed to detect p63 expression.
Main Results:
- Keratocystic odontogenic tumors (KCOTs) showed the highest levels of p63 expression.
- Statistically significant differences in p63 expression were observed among the three cyst groups.
- p63 expression varied notably between KCOTs and the other cyst types.
Conclusions:
- p63 protein expression may serve as a useful marker for identifying odontogenic cysts with aggressive and invasive potential.
- Elevated p63 levels could indicate a more aggressive phenotype in odontogenic lesions.
- Further research can explore p63's role in predicting prognosis and guiding treatment decisions.
