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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

P53 and its implication in apoptosis (review)

C Gotz, M Montenarh

    International Journal of Oncology
    |May 11, 2011
    PubMed

    Insights

    The tumor suppressor protein p53 regulates the cell cycle and DNA repair, acting as a

    Area of Science:

    • Molecular Biology
    • Cell Biology
    • Genetics

    Background:

    • The tumor suppressor protein p53 is a critical regulator of cellular processes.
    • p53 interacts with various target proteins, influencing cell cycle progression.
    • p53 plays a dual role in cell cycle regulation, acting as both a positive and negative regulator.

    Purpose of the Study:

    • To elucidate the multifaceted roles of the p53 protein in cell cycle control.
    • To explore the involvement of p53 in DNA damage response, including growth arrest and repair.
    • To discuss the function of p53 in initiating programmed cell death (apoptosis) and its clinical implications.

    Main Methods:

    • Interaction analysis of p53 with its known targets (WAF1/CIP1, mdm2, GADD45).
    • Investigation of p53's role in cell cycle arrest at the G(1) phase post-DNA damage.
    • Examination of p53's influence on the apoptotic cascade.

    Main Results:

    • p53 acts as a crucial 'guardian of the genome' by mediating cell cycle arrest and DNA repair after damage.
    • p53 significantly influences the initiation and execution of apoptosis, a programmed cell death pathway.
    • The protein's involvement in apoptosis suggests potential clinical relevance.

    Conclusions:

    • The tumor suppressor p53 is a key mediator of cell cycle arrest, DNA repair, and apoptosis.
    • p53's 'guardian of the genome' function is vital for preventing genomic instability.
    • The role of p53 in apoptosis highlights its importance in cancer therapy and disease progression.

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