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Related Concept Videos

Organization of the Brain01:30

Organization of the Brain

The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
Neurons as Communicators of the Brain01:22

Neurons as Communicators of the Brain

Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Brainstem01:19

Brainstem

The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
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Related Experiment Video

Updated: Jun 2, 2026

Simultaneous Cryosectioning of Multiple Rodent Brains
06:37

Simultaneous Cryosectioning of Multiple Rodent Brains

Published on: September 18, 2018

A few thoughts on brain ROIs.

Tianming Liu1

  • 1Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, GA 30602, USA. tliu@cs.uga.edu

Brain Imaging and Behavior
|May 11, 2011
PubMed
Summary
This summary is machine-generated.

Defining optimal brain Regions of Interests (ROIs) is crucial for accurate mapping of human brain connectivity. This study addresses key challenges in ROI selection for reliable structural and functional connectivity analysis.

More Related Videos

Collection of Frozen Rodent Brain Regions for Downstream Analyses
07:06

Collection of Frozen Rodent Brain Regions for Downstream Analyses

Published on: April 23, 2020

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

Related Experiment Videos

Last Updated: Jun 2, 2026

Simultaneous Cryosectioning of Multiple Rodent Brains
06:37

Simultaneous Cryosectioning of Multiple Rodent Brains

Published on: September 18, 2018

Collection of Frozen Rodent Brain Regions for Downstream Analyses
07:06

Collection of Frozen Rodent Brain Regions for Downstream Analyses

Published on: April 23, 2020

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Brain Connectivity

Background:

  • Quantitative mapping of human brain connectivities using non-invasive neuroimaging is vital for understanding brain architecture.
  • Altered connectivities are implicated in various brain diseases, making their assessment a cornerstone of clinical neuroscience.

Purpose of the Study:

  • To address the fundamental challenge of defining and localizing optimal Regions of Interests (ROIs) for brain connectivity mapping.
  • To discuss critical issues in establishing reliable, reproducible, and accurate ROIs for both structural and functional connectivity analysis.

Main Methods:

  • The study focuses on the conceptual and methodological challenges in ROI definition for brain connectivity.
  • It draws upon recent research from the authors' group to propose solutions.

Main Results:

  • Identification of key challenges in defining optimal brain ROIs for connectivity mapping.
  • Presentation of potential strategies to overcome these challenges based on current research.

Conclusions:

  • Accurate and reproducible ROI definition is paramount for successful brain connectivity mapping.
  • Addressing the discussed challenges is essential for advancing clinical neuroscience research.