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A gene for cytochrome c oxidase subunit III (COXIII) in broad bean mitochondrial DNA: structural features and
J L Macfarlane1, J A Wahleithner, D R Wolstenholme
1Department of Biology, University of Utah, Salt Lake City 84112.
Abstract:
A nucleotide sequence of broad bean mitochondrial DNA (mtDNA) that contains the coxIII gene is presented, and compared to corresponding sequences of Oenothera and corn mtDNAs. Upstream from the broad bean coxIII gene are three potential secondary structures: a single stem and loop (hairpin) that is conserved in the Oenothera and corn sequences; a second single stem and loop; and a double stem and loop. The rate of evolution of the coxIII gene has been slower in plants than in mammals. Constraints on the fixation of at least some kinds of mutations in silent (synonymous) third position nucleotides, as well as of mutations that cause amino acid replacements, seem to have contributed to this slower rate.