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Endoscopic, clinicopathological features and prognosis of very young patients with gastric cancer

Yu Bai1, Zhao-Shen Li

  • 1Digestive Endoscopy Center, Department of Gastroenterology, Changhai Hospital, Shanghai, China.

Journal of Gastroenterology and Hepatology
|May 12, 2011
PubMed

Insights

Gastric cancer in young patients (<35 years) often affects females and shows a high family history rate. Long-term prognosis is similar to older patients if curative surgery is performed.

Area of Science:

  • Oncology
  • Gastroenterology
  • Clinical Medicine

Background:

  • Limited clinical data exists for gastric cancer in patients under 35 years old.
  • This demographic represents a unique patient group with distinct characteristics.

Purpose of the Study:

  • To investigate the endoscopic and clinicopathological features of gastric cancer in very young patients.
  • To analyze the long-term prognosis of this unique patient cohort.

Main Methods:

  • Prospective review of an endoscopy database for consecutive very young gastric cancer patients.
  • Analysis of patient demographics, clinical presentation, endoscopic and pathological findings.
  • Comparison of outcomes between very young and elderly gastric cancer patients.

Main Results:

  • 210 patients (median age 31) were analyzed; 60% were female.
  • 34.3% presented with alarm features; 19% had a family history of gastric cancer.
  • Cancers were mainly diffuse type (63.8%), located in the gastric body (58.1%). Curative surgery was performed in 18.1%, with a 5-year survival rate of 42.1%.

Conclusions:

  • Very young gastric cancer patients are predominantly female, with less frequent alarm features but a higher family history prevalence.
  • Gastric cancers in this group often occur in the gastric body and are diffuse type.
  • Long-term prognosis is comparable to elderly patients when curative surgical resection is achieved.
Abstract

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