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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
High risk bladder cancer: current management and survival
Anna M Leliveld1, Esther Bastiaannet, Benjamin H J Doornweerd
1Department of Urology, University Medical Center Groningen, Groningen, The Netherlands. a.m.leliveld@uro.umcg.nl
Summary
Eighteen percent of high-risk non-muscle invasive bladder cancer (NMIBC) patients received only transurethral resection (TUR). Older age and non-teaching hospital treatment were linked to less adjuvant therapy post-TUR, but did not affect recurrence or progression.
Area of Science:
- Urology
- Oncology
- Cancer Research
Background:
- High-risk non-muscle invasive bladder cancer (NMIBC) requires careful management to prevent recurrence and progression.
- Understanding patterns of care is crucial for optimizing treatment strategies in NMIBC.
Purpose of the Study:
- To evaluate the pattern of care for high-risk NMIBC patients within the Comprehensive Cancer Center North-Netherlands (CCCN).
- To identify factors influencing treatment choices, recurrence rates, and progression-free survival in high-risk NMIBC.
Main Methods:
- Retrospective analysis of 412 patients diagnosed with high-risk NMIBC.
- Data collected from the CCCN Cancer Registry and medical records, including clinical, demographic, and follow-up information.
- Univariate and multivariate analyses were performed to assess treatment factors and survival outcomes.
Main Results:
- Only 18% of patients with high-risk NMIBC underwent transurethral resection (TUR) as their sole treatment.
- Adjuvant treatment post-TUR was more common in teaching hospitals (90.7%) than non-teaching hospitals (71.8%).
- Older age and treatment in non-teaching hospitals were associated with reduced adjuvant treatment post-TUR. Recurrence affected 49% and progression 21.4% of patients.
Conclusions:
- A significant proportion of high-risk NMIBC patients received TUR as a single modality treatment.
- Age and hospital type influenced the utilization of adjuvant therapy after TUR.
- No significant association was found between patient/treatment variables and 5-year recurrence or progression rates.
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