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Polyneuropathies in paediatrics.

B Hagberg1

  • 1Department of Paediatrics II, Ostra Sjukhuset, Gothenburg, Sweden.

European Journal of Pediatrics
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

This review covers non-acute pediatric polyneuropathies (PNPs), focusing on treatable dysimmune PNPs, common hereditary neuropathies, and often missed symptomatic neuropathies. Metabolic screening is not informative for hereditary neuropathies unless a specific neurometabolic disorder is suspected.

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Area of Science:

  • Pediatric Neurology
  • Clinical Neuroscience
  • Genetics

Background:

  • Non-acute polyneuropathies (PNPs) are a diverse group of neurological disorders affecting children.
  • Key categories include dysimmune PNPs, hereditary neuropathies, and symptomatic neuropathies associated with other genetic disorders.
  • Accurate diagnosis is crucial for appropriate management and prognosis.

Purpose of the Study:

  • To review non-acute pediatric polyneuropathies (PNPs).
  • To highlight three main etiological groups: dysimmune, hereditary, and symptomatic neuropathies.
  • To discuss diagnostic approaches and the utility of metabolic screening.

Main Methods:

  • Literature review of non-acute pediatric polyneuropathies.
  • Categorization of PNPs into dysimmune, hereditary, and symptomatic groups.

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  • Analysis of diagnostic procedures and metabolic screening relevance.

    • Main Results:

    • Dysimmune PNPs, such as chronic relapsing dysimmune polyneuropathies (CRDP), are rare but treatable.
    • Hereditary motor/sensory neuropathies (HMSN and HSN) are more common.
    • Symptomatic neuropathies in heredodegenerative and neurometabolic disorders are often overlooked.

    Conclusions:

    • Metabolic screening provides no diagnostic information for HMSN, HSN, heredoataxias, or heredoparaplegias.
    • Targeted investigations are required when a specific neurometabolic disease is suspected based on clinical presentation.
    • A comprehensive diagnostic strategy is essential for managing pediatric non-acute polyneuropathies.