Related Experiment Videos
MK-801 potently inhibits alcohol withdrawal seizures in rats
R A Morrisett1, A H Rezvani, D Overstreet
1Department of Medicine (Neurology), Duke University Medical Center, Durham, NC.
European Journal of Pharmacology
|January 25, 1990
Abstract:
The ability of MK-801, an N-methyl-D-aspartate (NMDA)-channel antagonist, to suppress alcohol withdrawal seizures generated audio-genically was studied in adult male rats using a cross-over experimental design. MK-801 treatment reduced overall seizure score and proportion of rats seizing. In comparison to other seizure models, alcohol withdrawal seizures seem to be particularly sensitive to MK-801, suggesting that mechanisms which result in seizure susceptibility after withdrawal of chronic ethanol exposure may be dependent upon sensitization or upregulation of NMDA processes.