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Endothelin receptors in cultured renal epithelial cells
D Neuser1, S Zaiss, J P Stasch
1Institute of Pharmacology, Bayer AG, Wuppertal 1, F.R.G.
European Journal of Pharmacology
|February 6, 1990
Abstract:
We demonstrated the presence of specific binding sites for endothelin in the renal epithelial cell lines. MDCK and LLC-PK1. Endothelin binding induced mobilisation of intracellular calcium, as shown by an increase in 45Ca2+ efflux. This suggests a direct effect of endothelin on renal reabsorption in addition to the effects on the renal vasculature.