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Related Experiment Videos

The hormonal response to exercise in asthma.

J M Kallenbach1, V Panz, M S Girson

  • 1Dept of Medicine, University of the Witwatersrand, Johannesburg, South Africa.

The European Respiratory Journal
|February 1, 1990
PubMed
Summary

Asthmatic patients show an impaired cortisol response to exercise, suggesting a weakened adrenal function. This highlights the need for evaluating the hypothalamic-pituitary-adrenal axis in asthma management.

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Area of Science:

  • Endocrinology
  • Respiratory Medicine
  • Exercise Physiology

Background:

  • Asthma is a chronic respiratory condition.
  • Physical exercise can be a stressor.
  • Hormonal regulation during exercise is crucial.

Purpose of the Study:

  • To compare hormonal responses to exercise in asthmatic patients versus normal subjects.
  • To investigate plasma levels of growth hormone, prolactin, adrenocorticotropic hormone (ACTH), and cortisol.
  • To assess the hypothalamic-pituitary-adrenal (HPA) axis function in asthma during physical stress.

Main Methods:

  • Treadmill running protocol was used to induce exercise.
  • Plasma levels of key hormones were measured.
  • Comparison between 10 asthmatic patients and 12 healthy controls.

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Main Results:

  • Asthmatic patients exhibited an absence of plasma cortisol response to exercise.
  • No significant difference was observed between users and non-users of beclomethasone dipropionate.
  • The peak cortisol increment in asthmatics was significantly blunted compared to controls.

Conclusions:

  • Asthma may be associated with an impaired adrenocortical response to physical exercise.
  • The HPA axis function may be compromised in individuals with asthma.
  • Further evaluation of HPA axis function is warranted in asthma patients.