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Imaging Studies for Cardiovascular System V: CT

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...

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Related Experiment Video

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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4D micro-CT for cardiac and perfusion applications with view under sampling.

Cristian T Badea¹, Samuel M Johnston, Yi Qi

¹Center for In Vivo Microscopy, Box 3302, Duke University Medical Center, Durham, NC 27710,USA. Cristian.Badea@duke.edu

Physics in Medicine and Biology

|May 12, 2011

Summary

This study introduces advanced 4D micro-CT techniques for preclinical cardiac and pulmonary perfusion imaging in mice. These methods significantly reduce artifacts and improve image quality, enabling high-throughput longitudinal studies with low radiation doses.

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High Resolution 3D Imaging of Ex-Vivo Biological Samples by Micro CT

High Resolution 3D Imaging of Ex-Vivo Biological Samples by Micro CT

Published on: June 21, 2011

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Last Updated: Jun 2, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

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High Resolution 3D Imaging of Ex-Vivo Biological Samples by Micro CT

High Resolution 3D Imaging of Ex-Vivo Biological Samples by Micro CT

Published on: June 21, 2011

Area of Science:

Preclinical imaging
Medical physics
Biomedical engineering

Background:

Micro-computed tomography (micro-CT) is crucial for preclinical anatomical studies.
There is a growing need for functional measurements using 4D micro-CT.
Current methods face challenges in achieving high temporal and spatial resolution for dynamic processes.

Purpose of the Study:

To develop and validate strategies for 4D micro-CT imaging in preclinical applications.
To enable functional assessment of cardiac dynamics and pulmonary perfusion.
To overcome limitations of traditional reconstruction algorithms for dynamic micro-CT.

Main Methods:

Utilized a dual-source micro-CT system with a high projection rate (20/sec).
Developed retrospective gating for cardiac imaging using ECG and respiratory signals.
Implemented a multi-injection/rotation paradigm for pulmonary perfusion imaging.
Applied deconvolution algorithms to correct for angular inconsistencies and streaking artifacts caused by irregular projection distributions.
Incorporated data from prior images to fill gaps in reconstructions.

Main Results:

Achieved adequate image quality for 4D cardiac micro-CT in mice (88 µm isotropic voxel size, 10 ms temporal resolution).
Obtained 4D pulmonary perfusion images in mice (176 µm resolution, 687 ms temporal resolution).
Deconvolution reduced streaking artifacts by 70% and increased contrast-to-noise ratio by 2.5x compared to filtered backprojection (FBP).
Radiation doses were comparable to typical micro-CT studies (0.17-0.21 Gy).

Conclusions:

The proposed low-dose 4D micro-CT methods provide high-quality functional imaging for cardiac and pulmonary applications.
These techniques effectively address artifacts associated with dynamic scanning protocols.
The approach is suitable for high-throughput longitudinal studies in drug safety and cardiopulmonary phenotyping.