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Associations among periostin gene polymorphisms, clinical parameters and heart failure: a case-control study in 1104

Fangfang Wang1, Ying Song, Ye Jiang

  • 1Department of Cardiovascular Disease, Changzhou No. 2 People's Hospital, Affiliated Nanjing Medical University, Changzhou, Jiangsu Province, China.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|May 12, 2011
PubMed

Insights

Genetic variations in the periostin gene, specifically rs3829365, are linked to heart failure susceptibility and severity. Certain genotypes show protective effects in smokers and individuals with hypertriglyceridemia.

Area of Science:

  • Genetics and Cardiovascular Disease

Background:

  • Heart failure is a significant global health concern.
  • Genetic factors play a role in heart failure development and progression.

Purpose of the Study:

  • To investigate the association between periostin gene polymorphisms (rs3829365 and rs1028728) and heart failure in a Chinese population.
  • To explore the relationship between these polymorphisms and clinical parameters in heart failure patients.

Main Methods:

  • A case-control study involving 464 heart failure patients and 640 controls.
  • Genotyping of rs3829365 and rs1028728 using PCR and restriction fragment length polymorphism.
  • Multivariate logistic regression analysis to assess associations with clinical parameters and heart failure.

Main Results:

  • rs3829365 was significantly associated with heart failure (P = 0.043).
  • The CG or GG genotype of rs3829365 was an independent risk factor for heart failure (P = 0.015, OR = 1.88).
  • Specific genotypes of rs3829365 and rs1028728 demonstrated protective effects in smokers and individuals with hypertriglyceridemia, respectively.
  • Heart failure severity was associated with rs3829365 genotype.

Conclusions:

  • Periostin gene polymorphism rs3829365 may influence susceptibility and severity of heart failure.
  • Interactions between rs3829365 and smoking, and rs1028728 and hypertriglyceridemia require further investigation.
Abstract

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