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Higher adherence to French dietary guidelines and chronic diseases in the prospective SU.VI.MAX cohort
E Kesse-Guyot1, M Touvier, A Henegar
1UREN, U557 INSERM/U1125 INRA/CNAM/Paris 13 Université, CRNH IdF, Bobigny, France. e.kesse@uren.smbh.univ-paris13.fr
Background/Objectives:
Nutritional recommendations are widely disseminated, but assessment of their predictive value for risk of chronic diseases and mortality is essential for ensuring their validity. We evaluated, in a large population-based study, the association between the French Programme National Nutrition Santé (PNNS) Guideline Score (GS) (maximum score of 15 points), an a priori-based score, and the incidences of cancer, cardiovascular disease (CVD) and overall mortality.
Subjects/Methods:
Subjects included in this analysis (n=5823) were participants in the Supplémentation en Vitamines et Minéraux AntioXydants study, with available data for estimating the PNNS-GS. Hazards ratios (HRs) and 95% confidence intervals (95% CIs) for outcomes (cancer, CVD and death) were estimated across quartiles of PNNS-GS using Cox proportional hazards models.
Results:
A total of 734 major events were recorded during an average 11.6-year follow-up (maximum 13 years): 423 cancers, 193 ischemic diseases and 118 deaths. In the fully adjusted model, a significant reduction in CVD risk between the first and fourth PNNS-GS quartiles (HR=0.65, 95% CI=0.41, 1.00, P for trend=0.04) was observed. No significant overall association with risk of cancer or death was detected.
Conclusions:
These observations support the role of nutritional guidelines in prevention of CVD.
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