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Updated: Jun 2, 2026
11:12
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
ER81 Expression in Breast Cancers and Hyperplasia
Yuanyuan Wang1, Li Wang, Yue Chen
1Department of Pathology, Kunming General Hospital/Kunming Medical College, Kunming, Yunnan 650032, China.
Pathology Research International
|May 12, 2011
Summary
ER81 overexpression is linked to early breast cancer development and progression. This transcription factor
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- ER81 is a transcription factor with a potential role in breast cancer.
- Limited understanding exists regarding ER81's specific involvement in breast carcinogenesis.
- Investigating ER81 expression is crucial for understanding breast cancer development.
Purpose of the Study:
- To investigate the role of ER81 in breast carcinogenesis.
- To examine ER81 expression patterns across different stages of breast tissue development and malignancy.
- To correlate ER81 expression with clinical-pathological features of breast cancer.
Main Methods:
- Immunohistochemical staining was employed to assess ER81 expression.
- ER81 levels were analyzed in normal breast tissue (NBT), Hyperplastic Unequal Thickness (HUT), Atypical Ductal Hyperplasia (ADH), Ductal Carcinoma In Situ (DCIS), and Invasive Ductal Carcinoma (IDC).
- Statistical analysis was performed to determine the significance of ER81 expression differences and associations with clinical-pathological parameters.
Main Results:
- ER81 overexpression was detected in HUT (25.7%), ADH (41.2%), DCIS (54.5%), and IDC (63.0%).
- Significant differences in ER81 expression were observed between NBT and HUT, and between HUT and ADH (P < .05).
- ER81 expression was significantly associated with Her2 amplification and negatively associated with Estrogen Receptor (ER) and Progesterone Receptor (PR) expression.
Conclusions:
- ER81 overexpression is present in the early stages of breast development.
- These findings suggest ER81 plays a significant role in breast carcinogenesis.
- Targeting ER81 may offer potential therapeutic strategies for breast cancer.
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