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Updated: Jun 2, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Clear cell Basal cell carcinoma.

Deba P Sarma¹, Daniel Olson, Jennifer Olivella

¹Department of Pathology, Creighton University Medical Center, Omaha, NE 68131, USA.

Pathology Research International

|May 12, 2011

Summary

This summary is machine-generated.

Clear cell basal cell carcinoma (BCC) is a rare BCC variant with clear cells. Accurate identification of this unusual tumor is crucial for appropriate treatment and prognosis.

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Published on: May 11, 2016

Area of Science:

Dermatology
Oncology
Pathology

Background:

Clear cell basal cell carcinoma (BCC) is an uncommon histological variant of BCC.
Its pathogenesis and clinical significance remain poorly understood.
Distinguishing clear cell BCC from other clear cell tumors is essential for patient management.

Observation:

A 65-year-old male presented with a 0.9 cm dome-shaped lesion on his upper chest.
Shave biopsy revealed a dermal basaloid tumor with clear cell changes, peripheral palisading, and retraction artifacts.

Findings:

Histopathologic examination confirmed the diagnosis of clear cell basal cell carcinoma.
Immunohistochemical studies and special staining supported the presence of clear cells.

Implications:

Clear cell BCC is a rare variant requiring accurate diagnosis.
Understanding its pathogenesis may influence treatment strategies and patient prognosis.