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Related Concept Videos

Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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Activation of Integrins

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Integrins01:10

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Role Of Notch Signalling In Intestinal Stem Cell Renewal

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In vitro Organoid Culture of Primary Mouse Colon Tumors
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Integrin Beta-4 expression in colorectal-cancer.

R Falcioni1, V Turchi, P Vitullo

  • 1IST REGINA ELENA,CTR RIC SPERIMENTALE,ONCOGENESI MOLEC LAB,I-00158 ROME,ITALY. UNIV ROMA LA SAPIENZA,DIPARTIMENTO MED SPERIMENTALE,ROME,ITALY. UNIV FERRARA,IST CLIN CHIRURG,FERRARA,ITALY. UNIV FLORENCE,IST PATOL CHIRURG,FLORENCE,ITALY. UNIV G DANNUNZIO,IST PATOL UMANA,CHIETI,ITALY. IST REGINA ELENA,DIV CHIRURG 1,I-00158 ROME,ITALY.

International Journal of Oncology
|May 12, 2011
PubMed
Summary

Integrin alpha 6 beta 4 expression increases in colorectal tumors, particularly in advanced stages and poorly differentiated lesions. This suggests microenvironmental factors influence its role in tumor progression.

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Area of Science:

  • Cell Biology
  • Oncology
  • Biochemistry

Background:

  • Integrin alpha 6 beta 4 is crucial for epithelial interactions with basement membranes.
  • Its expression is significantly altered during tumor progression, especially in carcinomas.

Purpose of the Study:

  • To investigate the expression of the integrin alpha 6 beta 4 subunit in colorectal carcinomas and normal mucosa.
  • To correlate beta 4 expression levels with clinical stage, differentiation, and tumor growth patterns.

Main Methods:

  • Quantitative immunochemical assay and immunohistochemistry were used.
  • Expression of the beta 4 subunit of integrin alpha 6 beta 4 was analyzed in 25 primary carcinomas and matching normal mucosae.

Main Results:

  • Integrin alpha 6 beta 4 was expressed in all samples, with highest levels in high-stage (Dukes' C) tumors.
  • Beta 4 reactivity inversely correlated with tumor differentiation.
  • Expression patterns varied with tumor growth, showing strong expression in poorly differentiated areas and at the lumenal surface.

Conclusions:

  • Integrin alpha 6 beta 4 expression in colorectal tumors is influenced by microenvironmental factors.
  • Increased beta 4 expression is associated with high stage and poor differentiation in colorectal cancer.