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Recombinant ret oncogene products induce T-lymphocyte proliferation, and suppress lymphoma derived from ret

D Yan1, K Isobe, M Takahashi

  • 1NAGOYA UNIV,SCH MED,DEPT IMMUNOL,SHOWA KU,NAGOYA,AICHI 466,JAPAN. NAGOYA UNIV,SCH MED,DEPT PATHOL,SHOWA KU,NAGOYA,AICHI 466,JAPAN.

International Journal of Oncology
|May 12, 2011
PubMed

3Recombinant ret oncogene products in complete Freund's adjuvant were injected into normal mice and ret oncogene transgenic mice. Spleen cells from the mice immunized with ret proteins were highly proliferated in vitro by the stimulation of ret proteins. The proliferating T cells have CD4(+) phenotype and secreated CTLL-2 reactive interleukins. The peritoneal exudate cells from ret protein-immunized mice suppressed ret-2 lymphoma, which was derived from ret lymphoma transgenic mice. The peritoneal exudate cells from ret melanoma transgenic mice did not suppress ret-2 lymphoma, when they were immunized with ret proteins.

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