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Updated: Jun 2, 2026
09:29
Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
Hormone-dependent human tumors express the fms gene-product
1NARA MED UNIV,DEPT PATHOL 2,KASHIHARA,NARA 634,JAPAN. OSAKA MED COLL,CTR ANIM LAB,TAKATSUKI,OSAKA 569,JAPAN. UNIV OSAKA PREFECTURE,ADV SCI & TECHNOL RES INST,DEPT APPL BIOSCI,SAKAI,OSAKA 593,JAPAN. KURUME UNIV,SCH MED,DEPT PATHOL 2,KURUME,FUKUOKA 830,JAPAN. MED COLL GEORGIA,DEPT IMMUNOL & MICROBIOL,AUGUSTA,GA 30912.
International Journal of Oncology
|May 12, 2011
Summary
Amplification of the fms oncogene was found in most human breast tumors, and its product was highly expressed in hormone-responsive cancers. This suggests fms may be a valuable marker for human mammary tumors.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- The FMS gene, encoding a receptor tyrosine kinase, plays a role in cell growth and differentiation.
- Aberrant expression and amplification of oncogenes are implicated in tumorigenesis.
Purpose of the Study:
- To investigate the amplification and expression of the FMS oncogene in human mammary and thyroid tumors.
- To determine the potential of FMS as a biomarker for human mammary tumors.
Main Methods:
- DNA analysis was performed to detect FMS gene amplification and rearrangement in tumor samples.
- Immunohistochemical staining using a polyclonal antibody was employed to assess FMS gene product expression.
Main Results:
- FMS gene amplification was observed in 86% of analyzed human mammary tumors, but not in thyroid tumors or peripheral blood cells.
- FMS gene product expression was significantly higher in hormone-dependent tumors (38-97%) compared to hormone-independent tumors (20-42%).
- FMS gene product expression was not detected in normal surrounding tissues.
Conclusions:
- FMS gene amplification is frequent in human mammary tumors.
- The expression of FMS gene product is associated with the development of hormone-responsive tumors, particularly breast cancer.
- FMS gene product shows potential as a valuable biomarker for human mammary tumors.
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