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A study on the oncogenes gli, fos, jun and met in human uterine leiomyomas

G Havel1, N Heldin, B Wedell

  • 1UNIV UPPSALA,INST PATHOL,DEPT TUMOUR BIOL,S-75185 UPPSALA,SWEDEN.

International Journal of Oncology
|May 12, 2011
PubMed

Insights

Researchers analyzed 122 uterine leiomyomas for chromosomal aberrations and oncogene rearrangements. Rearrangement of the met oncogene was found in only one leiomyoma with a specific chromosomal marker.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Uterine leiomyomas are common benign tumors associated with chromosomal abnormalities.
  • Specific chromosomal breakpoints in leiomyomas often involve regions with known oncogenes.

Purpose of the Study:

  • To investigate the potential involvement of four specific oncogenes (gli, fos, jun, met) in the development of human uterine leiomyomas.
  • To correlate chromosomal aberrations with oncogene rearrangements in leiomyoma tissue.

Main Methods:

  • Southern blotting technique was employed to analyze DNA from 122 human uterine leiomyomas.
  • Probes for the oncogenes gli, fos, jun, and met were used to detect potential gene rearrangements.

Main Results:

  • Chromosomal aberrations characteristic of leiomyomas were observed.
  • Rearrangement of the met oncogene was detected in only one leiomyoma exhibiting a 7p+q- chromosomal marker.
  • No rearrangements were found for the gli, fos, or jun oncogenes in the analyzed samples.

Conclusions:

  • The study suggests that chromosomal aberrations in uterine leiomyomas are not frequently associated with rearrangements of the investigated oncogenes (gli, fos, jun, met).
  • The met oncogene may play a role in a small subset of leiomyomas with specific chromosomal abnormalities.

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