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Updated: Jun 2, 2026
Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker
Published on: September 15, 2023
Differential expression of hsp90, gelsolin and gst-pi in human gastric-carcinoma cell-lines
S Moriya1, K Yanagihara, H Fujita
1HOKKAIDO UNIV,SCH MED,INST CANC,MOLEC GENET LAB,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN. HOKKAIDO UNIV,SCH DENT,DEPT ORAL SURG 1,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN. HIROSHIMA UNIV,NUCL MED & BIOL RES INST,DEPT PATHOL,MINAMI KU,HIROSHIMA 734,JAPAN.
Abstract:
We have analyzed proteins produced in Various human gastric carcinoma cell lines and normal gastric mucosa. The production of HSP90 increased in eight gastric carcinoma cell lines. Gelsolin content was down-regulated in seven gastric carcinoma cell lines. Furthermore, the production of GST-pi increased in a poorly differentiated adenocarcinoma cell line and two scirrhous gastric carcinoma cell lines. These results suggest that increased production of HSP90 and down-regulation of gelsolin play an important role in gastric carcinogenesis, and that abundant production of GST-pi is related to unique behavior of some scirrhous gastric carcinomas.