Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Suctioning the Nasopharyngeal Airway

Suctioning the Nasopharyngeal Airway

Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required

Cardiopulmonary Resuscitation II: ACLS Airway Management

Cardiopulmonary Resuscitation II: ACLS Airway Management

Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned under...

Cystic Fibrosis: Management

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic sinusitis...

Pneumonia V: Nursing management and Prevention

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment

Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques

Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques

Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway interventions are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

GDF15 (Growth/Differentiation Factor-15) Expression in Human Adipose Tissue and in Adipocyte Cell Lines.

Biomedicines·2026

Same author

Obesity- and Glucose-Dependent Differential Autophagy Marker Expression in Adipose Tissues and Adipocytes.

Obesity science & practice·2026

Same author

Oral losartan yields subtherapeutic airway exposure compared to nebulized delivery and fails to improve mucociliary clearance in cystic fibrosis.

Frontiers in pharmacology·2026

Same author

In-situ product recovery in microfluidic bioreactors.

Current opinion in biotechnology·2026

Same author

Establishment of a Single-Cell Minimal Medium: A Case Study for Microfluidic Cultivation of Corynebacterium glutamicum.

Biotechnology and bioengineering·2026

Same author

Age-Dependent Systemic Regulation of C1q/TNF-Related Protein 3 and Progranulin in Patients with Cystic Fibrosis: Biomarkers or Therapeutic Targets?

Biomedicines·2026

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Label-free Neutrophil Enrichment from Patient-derived Airway Secretion Using Closed-loop Inertial Microfluidics

Label-free Neutrophil Enrichment from Patient-derived Airway Secretion Using Closed-loop Inertial Microfluidics

Published on: June 7, 2018

Nucleotide-mediated airway clearance.

Andreas Schmid¹, Lucy A Clunes, Mathias Salathe

¹Division of Pulmonary and Critical Care, University of Miami, Miami, FL, 33136, USA, schmida.miami@gmail.com.

Sub-Cellular Biochemistry

|May 12, 2011

Summary

This summary is machine-generated.

The airway surface liquid (ASL) in the lungs is crucial for clearing mucus and pathogens. Purinergic signaling, involving ATP and adenosine, regulates key functions like ion transport and cilia beating for effective mucociliary clearance (MCC).

More Related Videos

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer

Published on: April 21, 2022

Related Experiment Videos

Last Updated: Jun 2, 2026

Label-free Neutrophil Enrichment from Patient-derived Airway Secretion Using Closed-loop Inertial Microfluidics

Label-free Neutrophil Enrichment from Patient-derived Airway Secretion Using Closed-loop Inertial Microfluidics

Published on: June 7, 2018

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer

Published on: April 21, 2022

Area of Science:

Pulmonary physiology
Cellular signaling

Background:

The airway surface liquid (ASL) is the lung's first defense against environmental exposures.
Surfactants and mucins within the ASL are vital for lung function and pathogen interception.
Mucociliary clearance (MCC) relies on cilia beating and ASL hydration via ion transport.

Purpose of the Study:

To comprehensively describe mucociliary clearance (MCC).
To detail the purinergic signaling network's extensive impact on pulmonary surfaces.
To explain the role of ATP and adenosine in regulating lung functions.

Main Methods:

Review of existing literature on ASL composition and function.
Analysis of purinergic signaling pathways involving P2Y2 and A2B receptors.
Description of the enzymatic conversion of ATP to adenosine.

Main Results:

Purinergic signaling, mediated by ATP and adenosine, controls ASL secretion, ion transport, and cilia beating.
ATP acts on P2Y2 receptors, while adenosine, derived from ATP, acts on A2B receptors.
This signaling network is integral to maintaining lung homeostasis and defense mechanisms.

Conclusions:

Purinergic signaling is a fundamental regulatory mechanism for MCC and overall lung health.
Understanding this network is key to addressing respiratory diseases.
The interplay between ATP, adenosine, and epithelial cells is critical for pulmonary defense.