[Effects on endocrine system of female rats exposed to chronic arsenic]
Zhiwei Guo1, Hongyu Guo, Yajuan Xia
1Inner Mongolia Medical College, Huhhot 010110, China. gzw84325@163.com
Objective:
To study the effect on endocrine system of female rats exposed to chronic arsenic.
Methods:
50 female Wistar rats were randomly divided into five groups: control group, 0.05, 0.1, 0.2 and 0.4 microg/ml arsenic groups. The hormone levels were determined by RIA exposing arsenic for 32 weeks.
Results:
The hormone levels of female rats were disorder in different arsenic groups. E2, P level increased and LH level decreased in arsenic groups compared to controls, but there were no significant differences( P > 0.05). FSH and PRL level increased in low arsenic group and decreased in high arsenic groups (P > 0.05). GnRH and Cort level increased in arsenic groups, and GnRH level obviously increased in 0.4 microg/ml group and Cort level obviously increased in 0.1 and 0.4 microg/ml groups (P < 0.05).
Conclusions:
The hormone levels were disordered in rats exposed to chronic arsenic.
