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Valproyl CoA: an active metabolite of valproate?
1Epilepsy Center, Harborview Medical Center, Seattle, WA 98104.
Medical Hypotheses
|January 1, 1990
Abstract:
Valproic acid exhibits a time course of antiepileptic effects suggesting a major role for active metabolites. It is proposed that valproyl-CoA, a valproate metabolite previously identified in liver, may accumulate in brain as a result of normal fatty acid turnover processes. Valproyl CoA could contribute to valproate's antiepileptic activity by stimulating Na+, K+-ATPase activity when brain ATP concentration is low.