Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design, Synthesis, and Biological Evaluation of Pseudo-Natural Products Inspired by Aryloctahydroindole Alkaloids.

ChemMedChem·2026
Same author

Covalent modification of a glutamic acid inspired by HaloTag technology.

Nature communications·2026
Same author

Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling.

Journal of medicinal chemistry·2026
Same author

Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3.

Nature chemistry·2026
Same author

Overcoming Ligand Discovery Challenges: Developing Peptide-Based Tracers for SPSB2.

ACS chemical biology·2025
Same author

Design, Synthesis, and Structural Evolution of Pseudo-Natural Product IDO1 Inhibitors and Degraders.

Angewandte Chemie (International ed. in English)·2025

Related Experiment Video

Updated: Jun 2, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
06:26

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

Exploring and exploiting biologically relevant chemical space.

Luc Eberhardt1, Kamal Kumar, Herbert Waldmann

  • 1Max-Planck-Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Straße 11, 44227 Dortmund, Germany.

Current Drug Targets
|May 13, 2011
PubMed
Summary

Chemists use natural products and synthesis strategies like Diversity Oriented Synthesis (DOS) and Biology Oriented Synthesis (BIOS) to find bioactive molecules. These approaches help discover chemical probes and drug candidates.

More Related Videos

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Related Experiment Videos

Last Updated: Jun 2, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
06:26

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Area of Science:

  • Medicinal Chemistry
  • Chemical Biology
  • Organic Synthesis

Background:

  • Bioactive molecules are essential for scientific discovery.
  • Bioactivity is not randomly distributed in chemical space, necessitating targeted strategies.
  • Natural products serve as inspiration and starting points for synthesizing compound libraries.

Purpose of the Study:

  • To explore strategies for identifying bioactive molecules.
  • To highlight the role of natural products, Diversity Oriented Synthesis (DOS), and Biology Oriented Synthesis (BIOS) in guiding synthesis.
  • To emphasize the need for integrated computational and synthetic approaches.

Main Methods:

  • Leveraging natural product structural motifs for library design.
  • Employing Diversity Oriented Synthesis (DOS) for diverse compound generation.
  • Utilizing Biology Oriented Synthesis (BIOS) to enrich collections with biologically relevant molecules.

Main Results:

  • Natural products provide validated scaffolds for drug discovery.
  • DOS and BIOS enable the creation of focused compound libraries.
  • Advancements in chemoinformatics and synthesis accelerate the identification of bioactive compounds.

Conclusions:

  • Targeted synthesis strategies are crucial for navigating chemical space.
  • Integrated computational and synthetic efforts are vital for discovering chemical probes and drug candidates.
  • Continued development in synthesis and bioinformatics will drive future discoveries in chemical biology and medicinal chemistry.