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Updated: Jun 2, 2026

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
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Cholesterol-induced conformational changes in the oxytocin receptor

Sabine Muth1, Anja Fries, Gerald Gimpl

  • 1Department of Biochemistry, Institute of Pharmacy and Biochemistry, Gutenberg-University Mainz, Johann-Joachim Becherweg 30, D-55128 Mainz, Germany.

The Biochemical Journal
|May 13, 2011
PubMed
Summary

Cholesterol binding affects G-protein-coupled receptors (GPCRs). This study shows cholesterol alters oxytocin receptor (OTR) dynamics, leading to a more compact receptor state by changing ligand orientation and distance.

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