Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurofibromatous neuropathy.

P K Thomas1, R H King, T R Chiang

  • 1Royal Free Hospital School of Medicine, Queen Square, London, UK.

Muscle & Nerve
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving patient and carer communication, multidisciplinary team working and goal-setting in stroke rehabilitation.

Clinical rehabilitation·2005
Same author

Sural nerve pathology in diabetic patients with minimal but progressive neuropathy.

Diabetologia·2005
Same author

Effects of aflatoxin B1 on embryo fetal development in rabbits.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2005
Same author

Matching supraclavicular fields to the extent of axillary surgery in women prescribed radiotherapy for early stage carcinoma of the breast.

Clinical oncology (Royal College of Radiologists (Great Britain))·2005
Same author

Repeat CT scan in closed head injury.

Injury·2005
Same author

Inadvertent insertion of nasogastric tube into the brain.

The Journal of the Association of Physicians of India·2005
Same journal

Join AANEM.

Muscle & nerve·2026
Same journal

Targeted Muscle Reinnervation for Management and Prevention of Symptomatic Neuroma.

Muscle & nerve·2026
Same journal

AANEM News & Insights.

Muscle & nerve·2026
Same journal

Fat-Fraction Quantification Using Three-Point Dixon Technique in Duchenne Muscular Dystrophy and Its Correlation With Clinical Progression and Genotypic Characteristics: A Single Centre One-Year Prospective Study.

Muscle & nerve·2026
Same journal

Characterizing Combined Central and Peripheral Demyelination-Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis.

Muscle & nerve·2026
Same journal

Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications.

Muscle & nerve·2026
See all related articles

Neurofibromatosis can cause rare chronic distal sensorimotor neuropathy, characterized by enlarged peripheral nerves. Nerve biopsies confirmed neurofibromatous pathology in these patients, highlighting a unique manifestation of the disease.

Area of Science:

  • Neurology
  • Genetics
  • Pathology

Background:

  • Neurofibromatosis is a genetic disorder that can lead to tumor formation.
  • Peripheral neuropathies are common complications, but specific types can be rare.

Observation:

  • Three patients with neurofibromatosis presented with chronic distal sensorimotor neuropathy.
  • A key clinical sign was diffuse nodular enlargement of peripheral nerves.
  • One patient had neurofibromatosis type 2 with a chromosome 22 deletion.

Findings:

  • Nerve biopsies revealed neurofibromatous pathology in all three cases.
  • This indicates a link between diffuse neurofibromatous changes and neuropathy.
  • Neurofibromatous neuropathy is a rare but distinct manifestation.

Related Experiment Videos

Implications:

  • Understanding this rare neuropathy improves diagnosis and management of neurofibromatosis complications.
  • Further research can elucidate the specific mechanisms linking neurofibromatosis to peripheral nerve pathology.
  • This case series contributes to the literature on rare neurological manifestations of genetic disorders.