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Preliminary evidence of within-subject changes in gray matter density associated with remission of bipolar depression

John O Brooks1, Lara C Foland-Ross, Paul M Thompson

  • 1Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024, USA. john.brooks@ucla.edu

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Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.