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Updated: Jun 2, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
Activation and effector functions of human RORC+ innate lymphoid cells
Ferry Cornelissen1, Patricia Aparicio Domingo, Rogier M Reijmers
1Department of Hematology, Erasmus University Medical Center, PO Box 2040, 3000CA Rotterdam, The Netherlands.
Abstract:
Innate lymphoid cells expressing the nuclear hormone receptor RORC have emerged as important players in human mucosal immunity. These cells combine innate modes of activation such as Toll-like receptor signaling with secretion of adaptive effector molecules including IL-2, BAFF and the Th17 cytokines IL-17 and IL-22. This endows these cells with the ability to rapidly respond to changes in cytokine milieu as well as changes in microbial composition and to affect both intestinal homeostasis and activation of adaptive immune cells.
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