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Outpatient aspirin desensitization for patients with aspirin hypersensitivity and cardiac disease

Merritt L Fajt1, Andrej A Petrov

  • 1Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.

Critical Pathways in Cardiology
|May 13, 2011
PubMed

Insights

Outpatient aspirin desensitization offers a safe and effective way for cardiac patients with aspirin hypersensitivity to resume treatment. This flexible protocol avoids hospital admission, making it convenient for patients requiring aspirin therapy.

Area of Science:

  • Allergy and Immunology
  • Cardiology
  • Pharmacology

Background:

  • Cardiac disease frequently necessitates aspirin therapy.
  • Aspirin hypersensitivity (IgE-mediated) requires alternative treatments.
  • Aspirin desensitization enables safe aspirin resumption for hypersensitive patients.

Purpose of the Study:

  • To evaluate the efficacy and safety of an outpatient, multiday aspirin desensitization protocol.
  • To assess this protocol for patients with IgE-mediated aspirin hypersensitivity.
  • To determine if outpatient desensitization is a viable alternative to inpatient protocols.

Main Methods:

  • Retrospective assessment of a multidose aspirin desensitization protocol.
  • Protocol administered in an allergy-immunology clinic (July 2006 - Dec 2009).
  • Involved 10-12 aspirin doses over 2-3 half-days, allowing patients to return home between sessions.

Main Results:

  • Nine cardiac patients with aspirin hypersensitivity underwent outpatient desensitization.
  • Eight patients (89%) were successfully desensitized.
  • No adverse reactions necessitated inpatient care.

Conclusions:

  • An outpatient, multiday aspirin desensitization protocol is safe and effective.
  • This approach benefits cardiac patients requiring aspirin therapy.
  • The protocol offers convenience by avoiding hospital admission and lengthy commitments.
Abstract

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