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Related Experiment Videos

[Polyneuropathy in type I multiple endocrine syndrome].

C Conri1, G Ducloux, A Lagueny

  • 1Service de Médecine interne, Centre François Magendie, Hôpital du Haut-Levêque, Pessac.

Presse Medicale (Paris, France : 1983)
|February 17, 1990
PubMed
Summary

Hypoglycemia from insulinomas can cause peripheral polyneuropathy. This case highlights acute axonal damage as a likely cause in a patient with multiple endocrine neoplasia syndrome.

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Area of Science:

  • Endocrinology
  • Neurology
  • Oncology

Background:

  • Peripheral polyneuropathy is a rare complication of hypoglycemia caused by insulinomas or islet cell tumors.
  • Multiple Endocrine Neoplasia (MEN) syndrome type I is an inherited disorder associated with tumors in endocrine glands.

Observation:

  • A young woman with MEN type I, presenting with multiple insulinomas and parathyroid adenomas, developed a predominantly motor, symmetrical polyneuropathy affecting upper and lower limbs.
  • Muscle biopsy revealed muscular atrophy and non-specific acute axonal lesions.

Findings:

  • The patient experienced subacute axonal damage, a likely cause of her polyneuropathy, following hypoglycemic episodes.
  • While hyperparathyroidism was considered, the acute axonal damage post-hypoglycemia was deemed a more probable etiology for the neuropathy.

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Implications:

  • This case underscores the importance of recognizing hypoglycemia-induced polyneuropathy in patients with insulinomas and MEN syndrome.
  • Early diagnosis and management of hypoglycemia are crucial to prevent or mitigate neurological deficits.
  • Further research may clarify the precise mechanisms linking hypoglycemia, hyperparathyroidism, and axonal damage in polyneuropathy.