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Functional Divisions of the Nervous System

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The nervous system, responsible for sensing, integrating, and responding to various stimuli, is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The PNS has two functional divisions: the sensory or afferent division and the motor or efferent division.
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Related Experiment Video

Updated: Jun 2, 2026

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Published on: November 11, 2022

[GABA: a functional duality? Transition during neurodevelopment].

C Cortes-Romero¹, F Galindo, S Galicia-Isasmendi

¹Instituto de Fisiologia, Facultad de Medicina, Benemerita Universidad Autonoma de Puebla, Mexico.

Revista De Neurologia

|May 13, 2011

Summary

Gamma-aminobutyric acid (GABA) receptors are crucial for central nervous system function. Understanding their diverse subunits and expression is key to treating neurological disorders like epilepsy and neurodevelopmental conditions.

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Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

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Published on: November 14, 2014

Studying the Integration of Adult-born Neurons

Studying the Integration of Adult-born Neurons

Published on: March 25, 2011

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Last Updated: Jun 2, 2026

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Published on: November 11, 2022

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABA_A Receptors

Published on: November 14, 2014

Studying the Integration of Adult-born Neurons

Studying the Integration of Adult-born Neurons

Published on: March 25, 2011

Area of Science:

Neuroscience
Molecular Biology
Pharmacology

Context:

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system.
GABAergic transmission is mediated by ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors.
Receptor function is influenced by cotransporters NKCC1 and KCC2, particularly during neurodevelopment.

Purpose:

To review the structure and diversity of GABA receptors.
To examine the role of GABA receptors in central nervous system physiological processes.
To discuss GABA receptors as pharmacological targets.

Summary:

GABA receptor structure and diversity are explored, with emphasis on neurodevelopment.
The dual excitatory and inhibitory roles of GABAergic transmission, influenced by cotransporters, are detailed.
The potential of GABA receptors as pharmacological targets, including allosteric modulation sites, is highlighted.

Impact:

Knowledge of GABA receptor subunit diversity and spatiotemporal expression is vital for organism viability.
Understanding GABA receptors offers potential therapeutic strategies for epilepsy, drug addiction, and neurodevelopmental disorders.
Further research into GABA receptor pharmacology may unlock treatments for severe neurological conditions.