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Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System
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Published on: September 20, 2018

Minimum important difference for validated instruments in women with urge incontinence.

Keisha Y Dyer1, Yan Xu, Linda Brubaker

  • 1Department of Reproductive Medicine, University of California-San Diego, La Jolla, California 92037-1300, USA. keishadyer@yahoo.com

Neurourology and Urodynamics
|May 13, 2011
PubMed
Summary

The minimum important difference (MID) for Urogenital Distress Inventory (UDI) and Incontinence Impact Questionnaire (IIQ) in women with urge-predominant incontinence was estimated. MIDs did not significantly change over time, providing valuable benchmarks for clinical trials.

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Area of Science:

  • Urology
  • Clinical Trials
  • Health Outcomes Research

Background:

  • The Minimum Important Difference (MID) quantifies the smallest change in a patient's score that indicates a meaningful improvement.
  • Accurate MID estimates are crucial for interpreting clinical trial results and assessing treatment effectiveness in urinary incontinence.
  • This study focuses on urge-predominant incontinence, a common condition affecting quality of life.

Purpose of the Study:

  • To estimate the MID for the Urogenital Distress Inventory (UDI), Incontinence Impact Questionnaire (IIQ), and Overactive Bladder Questionnaire (OAB-q).
  • To compare MID estimates derived from anchor-based and distribution-based methods.
  • To evaluate whether MID values change over an 8-month period in patients with urge-predominant incontinence.

Main Methods:

  • A sub-analysis of a multi-center trial involving 307 women with urge-predominant incontinence.
  • Anchor-based methods were used when correlation between anchors (Global Perception of Improvement, Patient Satisfaction Questionnaire, incontinence episodes) and instruments was ≥ 0.3.
  • Distribution-based methods included effect sizes (±0.2 SD, ±0.5 SD) and standard error of measurement (±1). Data were collected at 10 weeks and 8 months post-randomization.

Main Results:

  • Anchor-based MIDs for UDI ranged from -35 to -45; for the UDI irritative subscale, -15 to -25.
  • Distribution-based MIDs for UDI and IIQ were -10 to -25 and -19 to -49, respectively, indicating reduced bother and symptom severity.
  • OAB-q subscale MIDs ranged from +5 to +12 (improved quality of life) and -13 to -25 (reduced symptom severity).

Conclusions:

  • The estimated MIDs for urge-predominant urinary incontinence are -35 for UDI and -15 for the UDI irritative subscale.
  • Distribution-based MIDs were generally lower than anchor-based MIDs.
  • MID values for these instruments did not typically change significantly over the 8-month study period.