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Urinary Tract Calculi III: Medical Management

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...

Urinary Tract Calculi I: Introduction

Urinary Tract Calculi I: Introduction

Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...

Urinary Tract Calculi VI: Surgical Management

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...

Urinary Tract Calculi V: Nursing Management

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...

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Related Experiment Video

Updated: Jun 2, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

[Uric acid nephrolithiasis].

Bertrand Dussol¹

¹Centre de néphrologie et de transplantation rénale, hôpital de la Conception, 13385 Marseille Cedex 05. bertrand.dussol@ap-hm.fr

La Revue Du Praticien

|May 14, 2011

Summary

Uric acid nephrolithiasis, a common kidney stone type, is rising due to aging and metabolic diseases. Acidic urine pH, not just high uric acid levels, is the main cause, requiring alkali treatment.

Area of Science:

Nephrology
Urology
Metabolic Diseases

Context:

Uric acid nephrolithiasis accounts for 10% of kidney stones in industrialized nations.
Increasing prevalence of obesity and type 2 diabetes mellitus will drive future increases.
Aging populations contribute to the rising incidence of these stones.

Purpose:

To highlight the pathophysiological basis of uric acid nephrolithiasis.
To emphasize the role of urine pH in stone formation.
To discuss diagnostic and management strategies.

Summary:

The primary defect in uric acid nephrolithiasis is excessively acidic urine (pH < 5.5), not hyperuricosuria.
Undissociated uric acid has low solubility in acidic urine; solubility increases at higher pH.

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Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

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Published on: October 3, 2020

Insulin resistance may promote acidic urine via increased net acid excretion.

Impact:

Diagnosis relies on imaging like echography and tomodensitometry due to radiolucent stones.
Medical management focuses on alkali treatment to increase urine pH.
Reducing hyper-uricosuria is a secondary management goal.