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Updated: Jun 2, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Catalyst control in sequential asymmetric allylic substitution: stereodivergent access to N,N-diprotected unnatural
Paolo Tosatti1, Amanda J Campbell, David House
1School of Chemistry, University of Leeds, LS2 9JT Leeds, UK.
Abstract:
The sequential use of Cu-catalyzed asymmetric allylic alkylation, olefin cross-metathesis, and Ir-catalyzed asymmetric allylic amination allows the concise, stereodivergent synthesis of complex chiral amines with complete regiocontrol and good diastereoselectivity, exemplified by the synthesis of a pair of diastereoisomeric unnatural branched amino acid derivatives.
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