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Pigmentation

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Contact depigmentation induced by propyl gallate.

D Pandhi¹, A Vij, A Singal

¹Department of Dermatology and STD, University College of Medical Sciences and GTB Hospital, University of Delhi, Delhi, India.

Clinical and Experimental Dermatology

|May 14, 2011

Summary

Propyl gallate, found in lipstick, kumkum, and flip-flops, caused skin depigmentation in a patient. Patch testing confirmed propyl gallate as a new depigmenting agent.

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Area of Science:

Dermatology
Toxicology

Background:

Contact depigmentation is a rare condition.
Identifying the causative agent is crucial for patient management.

Observation:

A 41-year-old woman presented with depigmentation on multiple body sites.
Exposure included lipstick, liquid kumkum, and rubber flip-flops.

Findings:

Patch testing identified propyl gallate as the depigmenting agent.
Propyl gallate was a common ingredient in all implicated products.
This is the first report of propyl gallate causing contact depigmentation.

Implications:

Propyl gallate should be considered in cases of unexplained contact depigmentation.
Further research is needed to understand the mechanism of depigmentation by propyl gallate.
Awareness among dermatologists and consumers about potential depigmenting agents in common products is important.