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Updated: Jun 2, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Autoimmune progesterone dermatitis: a diagnosis easily missed
L M Toms-Whittle1, L H John, D J Griffiths
1Department of Dermatology, Great Western Hospital NHS Foundation Trust, Swindon, Wiltshire, UK.
Clinical and Experimental Dermatology
|May 14, 2011
Summary
Autoimmune progesterone dermatitis (AIPD) is a rare skin condition causing cyclical flares. Treatment with buserelin nasal spray led to complete symptom resolution in a patient with a long history of this condition.
Area of Science:
- Dermatology
- Endocrinology
- Immunology
Background:
- Autoimmune progesterone dermatitis (AIPD) is a rare condition characterized by cyclical skin eruptions.
- These flares often correlate with the luteal phase of the menstrual cycle when progesterone levels peak.
Observation:
- A 34-year-old woman presented with an 8-year history of severe itching and a rash linked to her menstrual cycle.
- Previous diagnoses for her persistent eruption had been elusive.
Findings:
- The patient experienced complete clearance of her dermatosis after treatment with buserelin nasal spray.
- This suggests a potential therapeutic benefit of GnRH agonists in managing AIPD.
Implications:
- AIPD should be considered in women with intractable, cyclical dermatological conditions.
- Further research into the mechanisms and treatment of AIPD is warranted.
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