Related Experiment Video

Updated: Jun 2, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

Longitudinal left ventricular strain in hypertrophic cardiomyopathy: correlation with nonsustained ventricular

Emanuel Correia1, Bruno Rodrigues, Luís Ferreira Santos

  • 1Hospital S. Teotónio, Viseu, Portugal. emanuelbaptista@gmail.com

Echocardiography (Mount Kisco, N.Y.)
|May 14, 2011
PubMed

Insights

Reduced myocardial strain in hypertrophic cardiomyopathy (HCM) patients predicts nonsustained ventricular tachycardia (NSVT). This 2D speckle tracking measure aids in sudden cardiac death (SCD) risk stratification.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Electrophysiology

Background:

  • Sudden cardiac death (SCD) risk stratification in hypertrophic cardiomyopathy (HCM) remains challenging due to limitations of current risk factors.
  • Myocardial deformation analysis using 2D speckle tracking offers a novel approach to assess regional left ventricular (LV) function and its correlation with myocardial disarray and fibrosis.

Purpose of the Study:

  • To investigate the relationship between myocardial strain parameters derived from 2D speckle tracking and the occurrence of nonsustained ventricular tachycardia (NSVT) in patients with HCM.
  • To evaluate the potential of strain analysis as a new tool for SCD risk stratification in HCM.

Main Methods:

  • Thirty-two consecutive patients diagnosed with HCM underwent standard echocardiography and 2D speckle tracking strain analysis.
  • Twenty-four-hour Holter monitoring was performed to detect NSVT, and echocardiographic parameters were correlated with its presence.

Main Results:

  • Nine patients (28%) experienced NSVT. These patients exhibited higher maximal LV thickness compared to those without NSVT.
  • Significant reductions in mid septal, apical septal, apical lateral strain, and mean longitudinal strain were observed in patients with NSVT.
  • Midseptal strain < -10.5% demonstrated high sensitivity (89%) and specificity (74%) for predicting NSVT, independent of age or maximum wall thickness.

Conclusions:

  • Lower end-systolic peak longitudinal strain, as measured by 2D speckle tracking, is a significant predictor of NSVT in HCM patients.
  • This strain parameter holds promise as a valuable tool for improving SCD risk stratification in the HCM population.
Abstract

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