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Updated: Jun 2, 2026

A Practical Guide to Phylogenetics for Nonexperts
Published on: February 5, 2014
KINALYZER, a computer program for reconstructing sibling groups
M V Ashley1, I C Caballero, W Chaovalitwongse
1Department of Biological Sciences, M/C 066, University of Illinois at Chicago, 845 W. Taylor Street, Chicago, IL 60607, USA. ashley@uic.edu
Abstract:
A software suite KINALYZER reconstructs full-sibling groups without parental information using data from codominant marker loci such as microsatellites. KINALYZER utilizes a new algorithm for sibling reconstruction in diploid organisms based on combinatorial optimization. KINALYZER makes use of a Minimum 2-Allele Set Cover approach based on Mendelian inheritance rules and finds the smallest number of sibling groups that contain all the individuals in the sample. Also available is a 'Greedy Consensus' approach that reconstructs sibgroups using subsets of loci and finds the consensus of the partial solutions. Unlike likelihood methods for sibling reconstruction, KINALYZER does not require information about population allele frequencies and it makes no assumptions regarding the mating system of the species. KINALYZER is freely available as a web-based service.
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