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Updated: Jun 2, 2026
14:34
A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
Published on: April 3, 2026
Structure-based lead identification of ATP-competitive MK2 inhibitors
Tjeerd Barf1, Allard Kaptein, Sander de Wilde
1Merck Research Laboratories, MSD, Oss, The Netherlands.
Bioorganic & Medicinal Chemistry Letters
|May 14, 2011
Abstract:
MK2 kinase is a promising drug discovery target for the treatment of inflammatory diseases. Here, we describe the discovery of novel MK2 inhibitors using X-ray crystallography and structure-based drug design. The lead has in vivo efficacy in a short-term preclinical model.
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