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Interference between PARPs and SIRT1: a novel approach to healthy ageing?
1Ecole Polytechnique Fédérale de Lausanne, Switzerland.
Aging
|May 14, 2011
Abstract:
Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.
