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Assessment of clopidogrel on the left ventricular ejection fraction in acute myocardial infarction

Pejman Khosravi1, Hasan Shemirani, Behnoud Hedayatpour

  • 1Clinical Resident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences (IUMS), Isfahan, Iran.

International Journal of Preventive Medicine
|May 14, 2011
PubMed

Insights

Clopidogrel effectively prevents reduced left ventricular (LV) function after ST-elevation myocardial infarction (STEMI). This medication improved left ventricular ejection fraction (LVEF) in STEMI patients over one month.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Left ventricular (LV) dysfunction is a significant cause of morbidity and mortality post-ST-elevation myocardial infarction (STEMI).
  • Maintaining LV function is crucial for patient outcomes following STEMI.

Purpose of the Study:

  • To investigate the efficacy of Clopidogrel in preventing reduced LV function in patients diagnosed with STEMI.
  • To assess the impact of Clopidogrel on left ventricular ejection fraction (LVEF) in STEMI patients.

Main Methods:

  • A prospective study involving 144 STEMI patients divided into two groups: a case group receiving Clopidogrel and a control group receiving standard STEMI therapy.
  • Left ventricular ejection fraction (LVEF) was measured by echocardiography on the 4th day and one month post-STEMI.
  • LVEF changes were compared within and between the Clopidogrel and control groups.

Main Results:

  • The Clopidogrel group showed a significant improvement in mean LVEF from 45.92% on day 4 to 52.15% at one month (P<0.001).
  • In contrast, the control group experienced a decrease in mean LVEF from 44.72% on day 4 to 42.71% at one month.

Conclusions:

  • Clopidogrel administration is associated with improved LVEF in STEMI patients.
  • The findings suggest Clopidogrel is effective in preventing the reduction of LVEF following STEMI.
Abstract

Keywords:
Heart failureMyocardial infarctionPrevention

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