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Updated: Jun 2, 2026

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
Published on: November 7, 2013
Tailoring nanocarriers for intracellular protein delivery
Zhen Gu1, Anuradha Biswas, Muxun Zhao
1Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, California 90095, USA. guzhen@mit.edu
This review explores nanocarrier strategies for delivering proteins inside cells. These methods offer promising applications in medicine, including cancer therapy and genetic disease treatment.
Area of Science:
- Biotechnology
- Nanomedicine
- Molecular Biology
Background:
- Proteins are vital for all biological processes.
- Targeted intracellular protein delivery is gaining significant interest.
- This approach has broad applications in medicine and research.
Purpose of the Study:
- To review recent advancements in intracellular protein delivery using nanocarriers.
- To discuss various nanocarrier systems for protein delivery.
- To analyze the pros, cons, and future directions of these technologies.
Main Methods:
- Survey of lipid-mediated colloidal systems.
- Review of polymeric nanocarriers.
- Analysis of inorganic and protein-mediated carriers.
Main Results:
- Various nanocarrier platforms enable effective intracellular protein delivery.
- Each method presents unique advantages and limitations.
- The field is rapidly evolving with significant potential.
Conclusions:
- Nanocarriers are key to advancing intracellular protein delivery.
- Further research is needed to overcome current challenges.
- Optimized nanocarrier systems will expand therapeutic and diagnostic applications.
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