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Intracystic negative pressure may promote bone formation around jaw cysts
Yi Zhao1, Qi-Bing Han, Bing Liu
1Department of Prosthodontics, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, Hubei Province, China. zhao-yi@163.com
Abstract:
The growth and enlargement of jaw cysts are associated with raised intracystic pressure and bone resorption surrounding the cysts. The major bone-resorbing cells are the osteoclasts. They are acting under the influence of local bone-resorbing factors: prostaglandins, proteinases and cytokines. It was found that positive pressure enhanced the expression of IL-1αmRNA and protein in epithelial cells of odontogenic keratocyst, and increased the secretion of matrix metalloproteinase and PGE2 in a co-culture of odontogenic keratocyst fibroblasts and epithelial cells. However, the signal intensities for IL-1αmRNA and protein in the epithelium were significantly decreased after marsupialization which relived intracystic pressure. Experimental study indicated that intermittent negative pressure could promote osteogenesis in human bone marrow-derived stroma cells (BMSCs) in vitro. We propose a hypothesis that bone formation around the cyst of the jaws would be stimulated by intracystic negative pressure.
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