Fast-neutron radiotherapy of nonsmall cell-carcinoma of the lung

To determine the efficacy of fast neutron (FN) for the treatment of non-small cell lung cancer, 112 patients with histologically proven adenocarcinoma or squamous cell carcinoma at a limited stage were studied to evaluate local control and survival, after treatment with either FNs or photons alone. The local control rate of adenocarcinoma in FN-treated patients attained 50%, which was significantly higher than that (<10%) of squamous cell carcinoma in FN-treated patients or that of both histological types of carcinoma in patients treated with photons alone. In accordance with this, the 5-year survival rate for the FN-treated patients with adenocarcinoma was significantly higher than that for FN-treated patients with squamous cell carcinoma or that for photon-treated patients with both histological types of disease. The present study clearly suggests the usefulness of FN in the treatment of adenocarcinoma of the lung, though it was a non-randomized trial.