Transforming growth-factor-alpha and factor-beta(1) levels in plasma and effusions from patients with cancer or
L Witters1, H Almondhiry, Y Matthews
1PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT MED,DIV MED ONCOL,HERSHEY,PA 17033. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT BIOSTAT,HERSHEY,PA 17033. TRITON DIAGNOST INC,ALAMEDA,CA 94501. BERLEX BIOSCI INC,ALAMEDA,CA 94501. CELTRIX LABS INC,PALO ALTO,CA 94303.
Abstract:
Transforming growth factors-alpha and -beta1 are thought to play a role in carcinogenesis. Using a sandwich linked immunosorbent assay, we have measured TGF-alpha and -beta1 levels in malignant human plasma and effusions. TGF-alpha and -beta1 plasma levels were not significantly different among normal volunteers, patients with solid tumors, and patients with hematologic malignancies (TGF-alpha, p=0.225; TGF-beta1, p=0.354). Statistically significant differences were also not found in levels between malignant and non-malignant effusions (TGF-alpha, p=0.327; TGF-beta1, p=0.095). However, a trend for the majority of elevated TGF-alpha or TGF-beta1 levels to be in malignant effusions warrants further studies with larger numbers of samples.
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