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Updated: Jun 2, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Expression of tyrosine kinases encoding protooncogenes in differentiating human leukemia-cells
M Gismann1, B Quack, A Barnekow
1UNIV MUNSTER,DEPT EXPTL TUMORBIOL,D-48149 MUNSTER,GERMANY.
Abstract:
We investigated the expression of the tyrosine kinase encoding proto-oncogenes c-src and fyn during in vitro differentiation of the human promyelocytic leukemia cell line HL-60 and an HL-60 derived cell line (HL-GOT) with an altered T-cell receptor gene. In HL-60 cells, the fyn and c-src encoded tyrosine kinases are activated in a differentiation-dependent manner, whereas in HL-60T cells high levels of pp59(fyn) and pp60(c-src) specific kinase activities are already present in the untreated cells. From the data obtained we conclude that untreated HL-60T cells represent a more differentiated type of cells compared to the untreated promyelocytic HL-60 cells.
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