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Updated: Jun 2, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
Published on: April 11, 2025
P-glycoprotein expression in non-hodgkins-lymphoma
1VICTORIA HOSP,DEPT HEMATOL,375 SOUTH ST,LONDON N6A 4G5,ONTARIO,CANADA. UNIV WESTERN ONTARIO,DEPT BIOSTATIST & EPIDEMIOL,LONDON N6A 4G5,ON,CANADA. VICTORIA HOSP,DEPT PATHOL,LONDON N6A 4G5,ONTARIO,CANADA. HARPER GRACE HOSP,DEPT PATHOL,DETROIT,MI 48201.
Abstract:
Tissues from twenty-nine patients with non-Hodgkin's lymphoma (NHL) were examined for the presence of the P-glycoprotein (Pgp), a transmembrane protein associated with multidrug resistance. Six of the 29 NHL (21%) expressed Pgp; 3 of 8 (38%) low grade and 3 of 16 (19%) intermediate grade. No relationship was found between Pgp expression and age, stage, lactate dehydrogenase levels, extranodal disease or previous chemotherapy exposure. Pgp was present in 3 of 13 (23%) complete responders and 3 of 11 (27%) partial or nonresponders (p>0.10) suggesting no direct association between treatment response and Pgp expression in this series.

